Protective effect of aqueous extract of Phyllanthus fraternus against bromobenzene induced changes on cytosolic glutathione S-transferase isozymes in rat liver

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Protective effect of aqueous extract of Phyllanthus fraternus against bromobenzene induced changes on cytosolic glutathione S-transferase isozymes in rat liver

The aim of this study was to investigate beneficial effect of aqueous extract of Phyllanthus fraternus (AEPF) on bromobenzene (BB) induced changes on cytosolic glutathione S-transferase (GST) isozymes in rat liver. Administration of BB significantly decreased the activity of GST, however, prior administration of AEPF prevented the BB induced decrease in GST activity. Further the cytosolic GSTs ...

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Purification and characterization of a new cytosolic glutathione S-transferase (glutathione S-transferase X) from rat liver.

A hitherto unknown cytosolic glutathione S-transferase from rat liver was discovered and a method developed for its purification to apparent homogeneity. This enzyme had several properties that distinguished it from other glutathione S-transferases, and it was named glutathione S-transferase X. The purification procedure involved DEAE-cellulose chromatography, (NH4)2SO4 precipitation, affinity ...

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Study of the Protective Effect of Livergol against Liver Toxicity Caused by Bromobenzene in Mice

Liver is a major organ of the body which can be exposed to various chemicals, drugs, and many other xenobiotics such as bromobenzene. Bromobenzene must be converted to its active metabolites to produce liver and kidney toxicity. Livergol is an herbal product which contains silymarin. The objective of this study was to find out the protective effect of livergol against liver toxicity induced by ...

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ژورنال

عنوان ژورنال: Biochemistry and Biophysics Reports

سال: 2017

ISSN: 2405-5808

DOI: 10.1016/j.bbrep.2017.04.001